Raysha Farah - National Cardiovascular Center Harapan Kita | LinkedIn (2024)

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• He has served 6 presidents. He lead the NIAID and NIH for nearly 50 years. He has won the medal of freedom, was the leading scientist that changed…

  

  He has served 6 presidents. He lead the NIAID and NIH for nearly 50 years. He has won the medal of freedom, was the leading scientist that changed…

  Liked by Raysha Farah

• Show respect. Wear a mask.#NewYorkTough

  

  Show respect. Wear a mask.#NewYorkTough

  Liked by Raysha Farah

• I received this letter from a farmer in northeast Kansas. His wife is ill and he is aging. He sent me 1 of 5 N95 masks he has from farming to pass…

  

  I received this letter from a farmer in northeast Kansas. His wife is ill and he is aging. He sent me 1 of 5 N95 masks he has from farming to pass…

  Liked by Raysha Farah

• Certificate of Completion: Analysis of Complex Survey Data

  Columbia University Mailman School of Public Health - Department of Epidemiology

  Issued Jul 2023

• Certificate of Achievement - Lenox Hill Neurosurgery BRAINterns Summer 2020 Program

  Lenox Hill Neurosurgery

  Issued Sep 2020

• Certificate of Completion - 2019 Revolutions in Biomedicine Summer Program

  Imperial College London

  Issued Jul 2019

• Certificate of Achievement in Biochemistry, Genetics, Immunology and Physiology

  Harvard Medical School

  Issued Dec 2017

• COVID-19 Response Volunteer

  Kementerian Pendidikan dan Kebudayaan (Ministry of Education and Culture Republic of Indonesia)

  Mar 2020 - Present 4 years 4 months

  Health

  Provide information communication and education towards Indonesian citizens to promote COVID-19 prevention and home management.

• 

  Learning Facilitator and Social Media Designer

  The Smart Teens Project in Collaboration with IDAI & American Academy of Pediatrics

  Sep 2021 - Present 2 years 10 months

  Health

  The Smart Teens Project is a social mastery and resilience training against tobacco and e-cigarette using e-learning and social media. I was accepted to become a learning facilitator for teenagers. Moreover, I also volunteered to help with media design to extend learning formats for teenagers against tobacco and e-cigarette use nowadays.

• Emergency Relief Volunteer

  Asian Medical Students' Association (AMSA) International

  Feb 2019 - Feb 2019 1 month

  Disaster and Humanitarian Relief

  I am successfully chosen from a pool of applicants to be a volunteer for Emergency Relief: Pandeglang, Serang, Lampung Selatan and Tanggamus. One of the main activities I did was giving medicine to the government medical team in the area and helping medical teams.

• Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS

  NeuroImage: Clinical April 25, 2022

  Amyotrophic lateral sclerosis (ALS) is characterized by transactive response DNA-binding protein 43 (TDP-43) pathology, progressive loss of motor neurons and muscle dysfunction. Here, we investigate the potential for neurite orientation dispersion and density imaging and diffusion tensor imaging (DTI) to detect microstructural changes in an experimental model of ALS with neuronal doxycycline (Dox)-suppressible overexpression of human TDP-43 (hTDP-43). In vivo diffusion-weighted imaging (DWI)…

  Amyotrophic lateral sclerosis (ALS) is characterized by transactive response DNA-binding protein 43 (TDP-43) pathology, progressive loss of motor neurons and muscle dysfunction. Here, we investigate the potential for neurite orientation dispersion and density imaging and diffusion tensor imaging (DTI) to detect microstructural changes in an experimental model of ALS with neuronal doxycycline (Dox)-suppressible overexpression of human TDP-43 (hTDP-43). In vivo diffusion-weighted imaging (DWI) was acquired 1- and 3- weeks following the initiation of hTDP-43 expression (post-Dox) to investigate whether neurite density imaging (NDI) and orientation dispersion imaging (ODI) are affected early in this preclinical model of ALS and if so, how these metrics compare to those derived from the diffusion tensor. Tract-based spatial statistics at 1-week post-Dox, i.e. very early in the disease stage, demonstrated increased NDI in TDP-43 mice but no change in ODI or DTI metrics. At 3-weeks post-Dox, a reduced pattern of increased NDI was observed along with widespread increases in ODI, and decreased fractional anisotropy (FA), apparent diffusion coefficient (ADC) and axial diffusivity (AD). A hypothesis driven analysis of the bilateral corticospinal tracts demonstrated that at 1-week post-Dox, ODI was significantly increased caudally but decreased in the motor cortex of TDP-43 mice. Decreased cortical ODI had normalized by 3-weeks post-Dox and only significant increases were observed. A similar, but inverse pattern in FA was also observed. Together, these results suggest a non-monotonic relationship between DWI metrics and pathophysiological progression with TDP-43 mice exhibiting significantly altered diffusion metrics consistent with early inflammation followed by progressive axonal degeneration. Importantly, significant group-wise changes were observed in the earliest stages of disease when subtle pathology may be more elusive to traditional structural imaging techniques.

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• Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

  Translational Neurodegeneration March 15, 2022

  Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in the course of disease in a transgenic mouse with doxycycline (Dox)-controlled expression of cytoplasmic human TDP-43 (hTDP-43ΔNLS), mimicking the key pathology implicated in ALS.

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• Four-Drug Regimens For Treatment of Multiple Myeloma: A Systematic Review on Their Efficacy and Safety

  European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) July 23, 2021

  Introduction: Despite multiple treatment options available for the treatment of Multiple myeloma (MM), the disease remains incurable and disease relapse ultimately occurs after a period of disease control. Our review aims to measure the efficacy and safety of four-drug regimens in terms of progression-free survival and disease responses. Methods: A comprehensive literature search yielded a total of 36429 articles. Our search strategy included the following MeSH terms: “multiple myeloma” and…

  Introduction: Despite multiple treatment options available for the treatment of Multiple myeloma (MM), the disease remains incurable and disease relapse ultimately occurs after a period of disease control. Our review aims to measure the efficacy and safety of four-drug regimens in terms of progression-free survival and disease responses. Methods: A comprehensive literature search yielded a total of 36429 articles. Our search strategy included the following MeSH terms: “multiple myeloma” and “antineoplastic agents”. Ten studies met the inclusion criteria: phase I/II trials, phase III trials, studies published after 2010, and use of four-drug regimens with clear documentation of outcomes such as overall response rates (ORR), progression-free survival (PFS), and overall survival (OS). Results: A total of ten studies with 2,416 patients were included. 2,275 patients had relapsed refractory MM (RRMM), and 141 patients had newly diagnosed MM (NDMM). Seven studies demonstrated a comparison between three-drug and four-drug regimens. Six studies reported four-drug regimens to be significantly superior to three-drug regimens in terms of ORR. Two of the three studies that did not make any such comparison, showed an ORR of more than 90% with four-drug regimens whereas one study reported an ORR of about 67%. Other parameters such as PFS and OS also showed the four-drug regimen as an effective MM strategy. Conclusion: Four-drug antineoplastic regimens significantly improve the responses in both newly diagnosed and relapsed/refractory multiple myeloma. However, data on survival is awaited. The cost and associated synergism in the toxicity profile need further analysis and follow-up.

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• Highest expression of GFP in TOP10 E. coli strain due to differences in OmpC promoter regulation.

  iGEM Foundation October 10, 2019

  The aim of this study is to characterize Part: BBa_K769001 which is a PompC-RBS-GFP-Double terminator in 3 different bacterial strains. In order to choose a suitable bacterial strain for our project, we used 3 different bacterial strains based on their cloning, subcloning and expression capabilities. For this study we will be using E. coli strains TOP10, which is a high-efficiency strain ideal for cloning large plasmids and BACs so has a high copy vector, DH5a, which maximizes transformation…

  The aim of this study is to characterize Part: BBa_K769001 which is a PompC-RBS-GFP-Double terminator in 3 different bacterial strains. In order to choose a suitable bacterial strain for our project, we used 3 different bacterial strains based on their cloning, subcloning and expression capabilities. For this study we will be using E. coli strains TOP10, which is a high-efficiency strain ideal for cloning large plasmids and BACs so has a high copy vector, DH5a, which maximizes transformation efficiency too, and BL21, which is an ideal strain for expression vectors. The presence of ompC promoter in the BBa_K769001 construct may lead to different expression and regulation of GFP on these bacterial strains hence we use this variety of bacterial strains. We will be using a plate reader to measure the fluorescence of the transformed bacterial strains.
  

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• Advanced Suturing Course – Lingkar Studi Bedah Plastik (LSBP)

  ASC

• Epidemiology: Analysis of Complex Survey Data

  -

• Foundations of Neuroscience

  BIOS S-50

• Introduction to Molecular and Cellular Biology

  BIOS S-1A

• Introduction to Organismic and Evolutionary Biology

  BIOS S1-B

• Medical Science Honours Research Project

  MED4302

• Medical Science Honours Research Skills

  MED4301

• Principles and Techniques of Molecular Biology

  BIOS S-12

• Programming Methodologies

  CS106A

• Assessing glymphatic clearance in preclinical models of neurodegenerative disorders

  Jul 2020 - Jul 2022

  One of the hallmarks of neurodegenerative disease is the accumulation of aggregated toxic proteins. These toxic waste proteins are removed from the brain by the glymphatic system, a waste clearance system for the brain that is largely disengaged during wakefulness and highly active during sleep. Recent evidence suggests that impairment of the glymphatic system may lead to the accumulation of aggregated toxic proteins and increased vulnerability to neurodegenerative diseases, such as motor…

  One of the hallmarks of neurodegenerative disease is the accumulation of aggregated toxic proteins. These toxic waste proteins are removed from the brain by the glymphatic system, a waste clearance system for the brain that is largely disengaged during wakefulness and highly active during sleep. Recent evidence suggests that impairment of the glymphatic system may lead to the accumulation of aggregated toxic proteins and increased vulnerability to neurodegenerative diseases, such as motor neuron disease (MND). One of the hallmarks of MND, is the accumulation of an essential protein known as TDP-43. This innovative study will employ gadolinium enhanced contrast MRI (Gd-MRI) to investigate glymphatic clearance in a preclinical model of TDP-43 pathology and correlate these outcomes with behavioral and histological measures.

• Investigating the safety and efficacy of drugs for Multiple Myeloma

  May 2021 - Aug 2021

  Multiple myeloma remains one of the diseases which does not have a cure. Furthermore, patients often experience relapse which happens after the administration of treatment. This research will investigate drug regimens that might reduce relapse and hopefully improve survival and disease progression.

• Utilization of Modified HB-EGF/EnvZ Chimeric Receptor and Fluorescence Protein as a Rapid Diagnostic Test of Diphtheria Toxin

  Mar 2019 - Nov 2019

  Diphtheria, a lethal disease caused by the toxigenic strain of Corynebacterium diphtheriae, afflicted Indonesia in December 2017 with 1/10 mortality rates upon 593 national cases. Complicated diagnostic methods and ambiguous symptoms were the main obstacles in giving the optimal treatment, according to physicians. Therefore, a fast and convenient novel approach to enhance diagnostic precision is needed to mitigate diphtheria immediately. In regards, our team focuses on developing the diagnostic…

  Diphtheria, a lethal disease caused by the toxigenic strain of Corynebacterium diphtheriae, afflicted Indonesia in December 2017 with 1/10 mortality rates upon 593 national cases. Complicated diagnostic methods and ambiguous symptoms were the main obstacles in giving the optimal treatment, according to physicians. Therefore, a fast and convenient novel approach to enhance diagnostic precision is needed to mitigate diphtheria immediately. In regards, our team focuses on developing the diagnostic tool using K-12 chimeric bacteria and green fluorescent protein (GFP) to enable the rapid detection of Diphtheria toxin upon binding. This novel technology is claimed to be fast, available, and easy-to-use—which sets stepping stones regarding the establishment of primary diagnostic tools for Diphtheria toxin worldwide. In addition, we aim to prevent future outbreaks using public education to enhance awareness regarding anti-hoax movements and introduce daily probiotic consumption to encounter low usages of probiotic in Indonesia.

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• Harvard Medical School Dean’s Scholarship

  Harvard Medical School

  May 2024

  A prestigious award given to a student who has exhibited academic excellence, persistence, resilience, and a commitment to advancing the position of the underserved and the underrepresented in their field of interest.

• Dean’s Award

  Dean of the Faculty of Medicine Universitas Indonesia

  May 2021

  Award given to the highest achieving research student from the Bachelor of Medical Science(Hons) program.

• Recipient for Ministry of Education and Culture Excellence Scholarship (Beasiswa Unggulan Kementrian Pendidikan dan Kebudayaan)

  Indonesian Ministry of Education and Culture

  Sep 2020

  Awarded a scholarship worth $51600 from the Indonesian Ministry of Education and Culture for full tuition payment of pursuing an undergraduate degree.

• 2020 International Study Scholarship

  Monash University

  Jul 2020

  Received a scholarship worth $10000 for students studying an honors program and undertaking medical research in Melbourne, Australia.

• Gold Medal Award for the International Genetically Engineered Machine Competition 2019

  iGEM Foundation

  Nov 2019

• International Undergraduate Scholarship

  University of Aberdeen

  Mar 2017

  Awarded the International Undergraduate Scholarship for entry to the University of Aberdeen in September 2017.

• Biology HL Diploma Subject Award

  Global Jaya School

  Jun 2016

  Bestowed a subject award for academic excellence and effort in the IB Biology HL subject.

• Multiple Subject Award Certificate

  Global Jaya School

  Dec 2014

  Honored with multiple IB subject awards for academic excellence.

• Honorary Certificate for the Participation in the Indonesian Diplomatic Reception in Ukraine

  The Ambassador of the Republic of Indonesia for Ukraine concurrently georgia and republic of armenia

  Sep 2013

• IELTS

  Score: 8.0/9.0

  Jan 2019

• Seleksi Bersama Masuk Perguruan Tinggi Negeri (Joint Entrance Selection of State Universities)

  Score: 98th Percentile

  May 2017

  Passed the SBMPTN selection. Admitted to the Bachelor’s Computer Engineering Undergraduate Degree program in Universitas Indonesia.

• Indonesian

  Native or bilingual proficiency

• English

  Native or bilingual proficiency

• Spanish

  Limited working proficiency

• International Federation of Medical Students’ Association (IFMSA)

  Research Exchange Student (Italy)

  Oct 2021 - Present

• American College of Physicians

  Medical Student Member

  Apr 2020 - Present

• The International Genetically Engineered Machine (iGEM) Foundation

  Undergraduate Team and Consulting Mentor

  Mar 2019 - Present